Phosphatidylserine (PS) is a phospholipid that can be found in food and in high concentration in the brain where it carries messages between brain cells
It improves cognitive activity and cognitive aging, memory and attention
It balances cortisol levels to help normalize the sleep cycle and it reduces stress
Methyltetrahydrofolate (MTHF) is a natural product and the biological active form of the folic acid (vitamin B9) and it plays an important role in the DNA replication and cell subdivision cycle
Supplementation of MTHF during pregnancy reduces many neural tube defects in infants such as spina bifida as well as oral and urinary tract defects
Due to the inability of humans to synthesise folate, it has be obtained from the diet or from a food supplement to prevent cardiovascular diseases, regulate homocysteine levels and help individuals with the enzymatic deficits
Spermidine is a natural compound found in food such as soy products, sunflower, mushrooms, legumes and whole grain. It has a global effect on human health by slowing down the general clock of the aging process and extending longevity
Studies show that it has a positive effect on cellular fitness being engaged in cardiovascular function, reduces cancer-related mortality and delays neurodegeneration
Research also has shown that its supplementation has a positive impact on memory performance in the aging population as it declines the progression to dementia and promotes a cognitive and brain health
Oleoylethanolamide is a natural product derived from the metabolism of oleic acid which is the most common monounsaturated fatty acid found in nature
OEA has been used in antiobesity therapies due to its effect in the regulation of body weight by suppressing appetite
OEA is a potent anti-inflammatory and antioxidant compound which has been studied for its effects to treat alcohol-use disorders
PEA is a food component synthesised and metabolised in animals and present in plants
It inhibits mastocites degranulation which leads to a number of health benefits in controlling inflammation and pain
Following the work of Rita Levi-Moltancini, a Nobel prize winner, the scientific community started to carry out studies for PEA as a natural analgesic and anti inflammatory agent
 Madeo F, Carmona-Gutierrez D, Kepp O, Kroemer G. Spermidine delays aging in humans. Aging (Albany NY), 10, (8) 2018
 Wirth, M., Schwarz, C., Benson, G. et al. Effects of spermidine supplementation on cognition and biomarkers in older adults with subjective cognitive decline (SmartAge)—study protocol for a randomized controlled trial. Alz Res Therapy 11, (36), 2019.
 Fu, J., Gaetani, S., Oveisi, F. et al. Oleylethanolamide regulates feeding and body weight through activation of the nuclear receptor PPAR-α. Nature 425, 90–93, 2003.
 Orio L, Alen F, Pavón FJ, Serrano A and García-Bueno B, Oleoylethanolamide, Neuroinflammation, and Alcohol Abuse. Front. Mol. Neurosci. (11) 490, 2019.
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